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KMID : 0378019710140070093
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New Medical Journal
1971 Volume.14 No. 7 p.93 ~ p.107
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Studies on pathogenesis of ratsilicosis by route of intravenous and intratracheal inoculation of various mycobacteria with pertracheal infusion of free silica particles
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Abstract
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Suspension of free silica particles was infused into the lungs of rats through trachea, and suspension of various mycobacteria injected to rats by intravenous route after 2 months of silica infusion. On the other hand suspension of mycobacteria was infused simultaneously with silica dust by trachea.
The pathological observation of the lungs and recovery of mycobacteria from the various organs were made at 4-6 months after injection of mycobacteria.
The results obtained were as follows:
1. Macroscopically, tubercle formation were observed from three groups, silica, silica with intra￢venous and intratracheal injection of mycobacteria, while such tubercles were not found in groups inoculated mycobacteria only.
2. Destruction and squamous metaplasia of bronchial epithelial cell, marked appearence of macrophage, collagen fiber and marked caseation of nodules in bronchus were microscopically observed in simul￢taneous infusion group.
In lung-parenchyma, marked infiltration of macrophage, marked proliferation of collagen fiber, atelectasis and congestion by pressure of nodules were observed.
3. Pathological changes of simultaneous infusion of silica dust and mycobacteria by trachea were more
marked than intravenous injection of mycobacteria with silica dust infused.
4. More colonies of mycobacteria were recovered in simultaneous infusion group than the inoculated
intravenously.
5. Severity of pathologic change of mycobacteria was observed as following order: photochromogon, nonphotochrornogen, rapid grower, mycobacterium tuberculosis and scotochromgen.
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